Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3 phosphorylation in a mouse model of asthma
نویسندگان
چکیده
J. Kelley Bentley, Huan Deng, Marisa J. Linn, Jing Lei, Gregoriy A. Dokshin, Diane C. Fingar, Khalil N. Bitar, William R. Henderson, Jr., and Marc B. Hershenson The Departments of Pediatrics and Communicable Diseases, Molecular and Integrative Physiology, and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan; and Department of Medicine, University of Washington, Seattle, Washington
منابع مشابه
Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma.
Increased airway smooth muscle (ASM) mass, a characteristic finding in asthma, may be caused by hyperplasia or hypertrophy. Cell growth requires increased translation of contractile apparatus mRNA, which is controlled, in part, by glycogen synthase kinase (GSK)-3beta, a constitutively active kinase that inhibits eukaryotic initiation factor-2 activity and binding of methionyl tRNA to the riboso...
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Increased medial arterial thickness is a structural change in pulmonary arterial hypertension (PAH). The role of smooth muscle hypertrophy in this process has not been well studied. Bone morphogenetic proteins (BMPs), transforming growth factor (TGF)-beta1, serotonin (or 5-hydroxytryptamine; 5-HT), and endothelin (ET)-1 have been implicated in PAH pathogenesis. We examined the effect of these m...
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